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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IMPDH2
All Species:
43.64
Human Site:
T477
Identified Species:
80
UniProt:
P12268
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P12268
NP_000875.2
514
55805
T477
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
Chimpanzee
Pan troglodytes
XP_516452
608
66107
T571
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
Rhesus Macaque
Macaca mulatta
XP_001110855
514
55766
T477
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
Dog
Lupus familis
XP_850933
514
55841
T477
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
Cat
Felis silvestris
Mouse
Mus musculus
P24547
514
55797
T477
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
Rat
Rattus norvegicus
NP_954530
514
55780
T477
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505397
665
73137
T628
D
I
G
A
K
S
L
T
L
V
R
A
M
M
Y
Chicken
Gallus gallus
NP_001025772
514
55540
T477
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
Frog
Xenopus laevis
NP_001082410
514
55431
T477
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
Zebra Danio
Brachydanio rerio
NP_958872
514
55692
T477
D
I
G
A
K
S
L
T
Q
L
R
A
M
M
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07152
537
57811
N500
D
I
G
A
N
S
I
N
K
L
R
D
M
I
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SA34
502
54033
Q465
D
L
G
A
S
S
L
Q
S
A
H
E
L
L
R
Baker's Yeast
Sacchar. cerevisiae
P50094
524
56375
T486
D
I
G
C
E
S
L
T
S
L
K
E
N
V
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.5
99.6
99.4
N.A.
98.8
98.4
N.A.
72.9
94.9
92.8
91.2
N.A.
64.9
N.A.
N.A.
N.A.
Protein Similarity:
100
84.5
99.8
99.6
N.A.
99.6
98.8
N.A.
75.1
97
95.3
95.9
N.A.
79.8
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
100
93.3
N.A.
53.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
100
100
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
47.8
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
65.7
77.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
93
0
0
0
0
0
8
0
77
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
100
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
0
16
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
93
0
0
0
0
8
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
77
0
0
0
8
0
8
0
0
0
0
% K
% Leu:
0
8
0
0
0
0
93
0
8
24
0
0
8
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
85
77
0
% M
% Asn:
0
0
0
0
8
0
0
8
0
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
70
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
85
0
0
0
8
% R
% Ser:
0
0
0
0
8
100
0
0
16
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
85
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
70
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
85
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _